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Selective Phosphodiesterase 4B Inhibitors: A Review
Mohammed Afzal Azam1, Naga Srinivas Tripuraneni1
1Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India.
Scientia Pharmaceutica
|April 9, 2015
Summary
Phosphodiesterase 4B (PDE4B) regulates cyclic adenosine monophosphate (cAMP) and is implicated in various diseases. This review details current PDE4B inhibitors, aiding the development of new, selective therapeutic agents.
Area of Science:
- Biochemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Phosphodiesterase 4B (PDE4B) regulates intracellular cyclic adenosine monophosphate (cAMP) levels.
- PDE4B is implicated in inflammatory diseases, schizophrenia, cancers, COPD, cardiac contractility, and psoriatic arthritis.
- PDE4B is a significant target for therapeutic drug development.
Purpose of the Study:
- To provide an updated review of investigated PDE4B inhibitors.
- To consolidate structural information on known PDE4B inhibitors.
- To facilitate the design of novel, selective, and potent PDE4B inhibitors.
Main Methods:
- Literature review of scientific publications.
- Analysis of structural data for PDE4B inhibitors.
- Synthesis of information on therapeutic potential.
Main Results:
- Numerous PDE4B inhibitors have been developed.
- A range of structural scaffolds for PDE4B inhibition are documented.
- The review compiles current knowledge on PDE4B inhibitor development.
Conclusions:
- PDE4B inhibitors represent a promising therapeutic strategy for various diseases.
- Understanding the structure-activity relationships of current inhibitors is crucial.
- Further research can leverage this information to create improved drug candidates.
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