Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Scale-Up Processes

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...

Compacting Factor test

Compacting Factor test

The compacting factor test is a method used to assess the workability of concrete. It is especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...

Rolling Resistance: Problem Solving

Rolling Resistance: Problem Solving

Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...

Equation of Motion: General Plane motion - Problem Solving

Equation of Motion: General Plane motion - Problem Solving

Consider a lawn roller with a mass of 100 kg, a radius of 0.2 meters, and a radius of gyration of 0.15 meters. A force of 200 N is applied to this roller, angled at 60 degrees from the horizontal plane. What will be the angular acceleration of the lawn roller?
The friction between the roller and the ground is characterized by two coefficients. The static friction coefficient is 0.15, while the kinetic friction coefficient is 0.1. These values are crucial in understanding the interaction between...

Design Example: Aggregate Gradation

Design Example: Aggregate Gradation

The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Solvatochromic-Chemometric Framework to Resolve Subtle Polarity Microenvironment Differences in Cycloalkanes Driven by Molecular Conformation and Substituent Effects: A Proof-Of-Concept for Advanced Aviation Fuel Design.

The journal of physical chemistry. B·2026

Same author

Investigating the effect of solvent polarity environment differences in electrolyte and non-electrolyte systems.

Journal of pharmaceutical sciences·2025

Same author

Enhancing drug solubilization using a surface-modified edible biopolymer through hot melt extrusion: A design space methodology.

Journal of pharmaceutical sciences·2025

Same author

Development of an excipient polarity screening tool for protein formulations via solvatochromism.

Journal of pharmaceutical sciences·2025

Same author

Octenyl succinic anhydride-modified starches as emulsifier agents: A comparative study emphasizing stability, rheology, and emulsion´s microstructure.

Journal of pharmaceutical sciences·2025

Same author

Fast-dissolving electrospun cellulose fiber-based matrices as modular oral dosage forms.

Journal of pharmaceutical sciences·2025

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

A dimensionless variable for the scale up and transfer of a roller compaction formulation.

Nathan Boersen¹, David Belair¹, Garnet E Peck¹

¹a Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , IN USA.

Drug Development and Industrial Pharmacy

|April 9, 2015

Summary

This study introduces a dimensionless variable to scale roller compaction processes between different equipment. This method aids in transferring formulations and predicting ribbon porosity, improving pharmaceutical manufacturing efficiency.

Keywords:

Dimensionless variable operating parameters ribbon porosity roller compaction scale up

More Related Videos

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Published on: April 10, 2017

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

Published on: June 12, 2019

Related Experiment Videos

Last Updated: Apr 15, 2026

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Published on: April 10, 2017

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

Published on: June 12, 2019

Area of Science:

Pharmaceutical Manufacturing
Chemical Engineering
Materials Science

Background:

Roller compaction is a key dry granulation technique in pharmaceuticals.
Current limitations include a lack of scalable parameter sets for equipment transfer.
This gap hinders efficient formulation development and manufacturing.

Purpose of the Study:

To investigate a dimensionless variable for scaling roller compaction parameters.
To establish a relationship between operating parameters, raw material attributes, and ribbon porosity.
To enable formulation transferability across different roller compaction equipment.

Main Methods:

Examined dimensionless variables for parameter transfer.
Hypothesized relationships between ribbon porosity and operating parameters.
Developed and tested a specific dimensionless variable (RP/RS*HFS*True Density*D²) for correlation with ribbon porosity.

Main Results:

The dimensionless variable showed a strong correlation with ribbon porosity.
Average differences in ribbon porosity between equipment ranged from 0.012 to 0.024.
The findings support the hypothesis that a dimensionless approach can facilitate equipment transfer.

Conclusions:

A dimensionless variable can effectively correlate roller compaction operating parameters with ribbon porosity.
This approach provides a foundation for scaling and transferring formulations between different equipment.
The study advances pharmaceutical dry granulation by offering a method for process optimization and transfer.