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Comparative study of oral and intramuscular atropine sulphate as a premedicant in paediatric age group
Insights
Oral atropine sulfate in children is as effective as an intramuscular injection for pre-surgery medication. This oral route avoids needle pricks and offers a similar duration of effect, improving the pediatric patient experience.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
- Clinical Medicine
Background:
- Atropine sulfate is commonly used as a premedicant in pediatric surgery.
- Traditional administration involves intramuscular injections, which can be distressing for children.
- Exploring alternative, less invasive administration routes is crucial for pediatric patient care.
Purpose of the Study:
- To compare the efficacy of orally administered atropine sulfate versus intramuscularly administered atropine sulfate in pediatric patients.
- To evaluate the effectiveness of oral atropine sulfate as a premedicant prior to surgery.
- To assess the duration of action of atropine sulfate in healthy children.
Main Methods:
- Pediatric patients received oral atropine sulfate at a dosage of 0.02 mg/kg, 70 minutes before surgery.
- A comparative group received intramuscular atropine sulfate at a dosage of 0.01 mg/kg, 35 minutes before surgery.
- The duration of effect was also studied in healthy children not undergoing surgery.
Main Results:
- Oral atropine sulfate demonstrated comparable efficacy to intramuscular atropine sulfate in the pediatric age group.
- The oral route eliminated the need for needle pricks, reducing patient distress.
- The duration of atropine sulfate's effect in healthy children was observed to be between 2.5 to 3 hours.
Conclusions:
- Oral administration of atropine sulfate is a viable and effective alternative to intramuscular injection for pediatric pre-medication.
- The oral route offers a more child-friendly approach, mitigating the fear associated with needles.
- The established duration of action supports its use in clinical practice for pre-anesthetic care.
Abstract:
The use of atropine sulphate in the paediatric age group as a premedicant orally in a dosage of 0.02 mg/kg body weight 70 minutes prior to surgery was found to be as effective as atropine sulphate given intramuscularly 35 minutes prior to surgery in a dosage of 0.01 mg/kg body weight. This avoids the unpleasant memory of needle prick; The duration of effect as studied in the normal healthy children not subjected to surgery was found to be 2 1/2-3 hours.