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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Tissue Injury: Inflammation and Repair01:28

Tissue Injury: Inflammation and Repair

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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Updated: Apr 15, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
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Innovation and wound healing.

Keith Harding1

  • 1Dean of Clinical Innovation, Head of Wound Healing Research Unit (WHRU), School of Medicine, Cardiff University, Cardiff, UK.

Journal of Wound Care
|April 9, 2015
PubMed
Summary

Medical innovation partnerships are crucial, yet wound care innovation lags behind. Chronic wounds present a global challenge needing advancements in technology, processes, and social approaches for better healing outcomes.

Area of Science:

  • Medical innovation
  • Biotechnology
  • Healthcare systems

Background:

  • Medical innovation has surged over the last century.
  • Innovation in wound care has remained notably slow.
  • Chronic wounds represent a significant global health burden requiring multifaceted solutions.

Purpose of the Study:

  • To highlight the need for enhanced innovation in wound care.
  • To underscore the importance of interdisciplinary partnerships in medical advancement.
  • To identify areas for technical, process, and social innovation in wound management.

Main Methods:

  • Review of current medical innovation trends.
  • Analysis of the state of wound care technology and processes.
  • Exploration of existing research and healthcare system collaborations.
Keywords:
chronic woundsinnovationwound healing

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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Main Results:

  • Despite advancements in medicine, wound care innovation has not kept pace.
  • Chronic wounds pose a substantial global health challenge.
  • Novel partnerships are emerging, but a deeper understanding of wound healing is necessary.

Conclusions:

  • Unique partnerships between academic research, biotech/pharmaceutical companies, and healthcare providers are essential for medical progress.
  • Significant opportunities exist for technical, process, and social innovation in chronic wound management.
  • Further research is required to fully understand and improve wound healing processes.