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Updated: Apr 15, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Urinary tract infections: epidemiology, mechanisms of infection and treatment options
Ana L Flores-Mireles1, Jennifer N Walker1, Michael Caparon2
11] Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA. [2].
Abstract:
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
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