Irreversible renal failure after intraperitoneal cisplatin administration. A case report

Intraperitoneal cisplatin has been used for localized tumor control to attain high intraperitoneal concentrations while minimizing systemic toxicity. We report on a woman who developed permanent renal failure following a single intraperitoneal dose of cisplatin. Probable factors contributing to this toxicity were mild renal insufficiency from prior intravenous cisplatin and failure to maintain brisk diuresis in the face of volume depletion due to severe vomiting. Although intraperitoneal cisplatin results in high intraperitoneal drug levels, serum levels similar to those seen with intravenous therapy may contribute to severe nephrotoxicity.