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Third-hand Smoke: Impact on Hemostasis and Thrombogenesis
Zubair A Karim1, Fatima Z Alshbool, Hari Priya Vemana
1*Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA; and †Department of Cell Biology and Neuroscience, University of California, Riverside, CA.
Journal of Cardiovascular Pharmacology
|April 9, 2015
Summary
Third-hand smoke (THS) exposure, the residual tobacco smoke, significantly increases thrombosis risk by making platelets hyperactive. This study demonstrates THS
Area of Science:
- Cardiovascular Science
- Toxicology
- Hematology
Background:
- Cigarette smoking, including first-hand and second-hand smoke, is a known risk factor for acute coronary thrombosis.
- Third-hand smoke (THS) is residual tobacco smoke contamination after extinguishment, with its thrombotic risk unestablished.
Purpose of the Study:
- To investigate the impact of third-hand smoke (THS) exposure on platelet biology.
- To determine if THS exposure enhances the risk of thrombogenesis.
Main Methods:
- Exposure of mice to third-hand smoke (THS).
- Assessment of platelet aggregation, secretion, and integrin GPIIb-IIIa activation.
- Evaluation of tail bleeding time and thrombosis model occlusion time.
Main Results:
- THS-exposed mice showed enhanced platelet aggregation, secretion, and integrin GPIIb-IIIa activation.
- THS exposure led to shortened tail bleeding time.
- THS exposure reduced occlusion time in a thrombosis model.
Conclusions:
- Third-hand smoke (THS) exposure increases thrombosis risk by promoting platelet hyperactivity.
- THS exposure contributes to thrombosis-based disease states, at least in murine models.
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