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Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis

C Zhang1, L Chen, Y Gu

  • 1Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, No 188 ShiziStreet, 215006, Suzhou, China.

Zeitschrift Fur Rheumatologie
|April 10, 2015
PubMed
Abstract

Insights

This meta-analysis found no significant link between rheumatoid arthritis (RA) and specific matrix metalloproteinase (MMP) gene polymorphisms (MMP-1 and MMP-3). Further research is needed to understand the role of these MMP gene variations in RA development.

Area of Science:

  • Genetics and Rheumatology
  • Molecular Biology
  • Disease Association Studies

Background:

  • Matrix metalloproteinase (MMP) genes, specifically MMP-1 and MMP-3, possess functional polymorphisms (1607 1G/2G and 1171 5A/6A) that have been hypothesized to contribute to rheumatoid arthritis (RA) development.
  • Previous research suggests a potential role for these MMP gene polymorphisms in the pathogenesis of RA, necessitating further investigation.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis to determine the correlation between rheumatoid arthritis (RA) and the MMP-1 (1607 1G/2G) and MMP-3 (1171 5A/6A) gene polymorphisms.
  • To validate the functional significance of these specific MMP gene polymorphisms in the context of RA risk.

Main Methods:

  • A systematic literature search was performed across multiple databases (PubMed, ISI Web of Knowledge, MEDLINE, Embase, Google Scholar, Chinese Biomedical Literature Database, Wanfang Data) to identify relevant case-control studies.
  • Studies investigating the association between MMP-1-1607 1G/2G and MMP-3-1171 5A/6A polymorphisms and RA risk were included.
  • Statistical analysis involved calculating pooled odds ratios (OR) with 95% confidence intervals (CI) to assess the strength of association.

Main Results:

  • Five articles met the inclusion criteria for the meta-analysis.
  • Neither the MMP-1-1607 1G/2G nor the MMP-3-1171 5A/6A polymorphism showed a statistically significant association with RA risk across all five genetic models.
  • Subgroup analysis for the MMP-3-1171 5A/6A polymorphism in Caucasian and Asian populations also revealed no significant association with RA.

Conclusions:

  • The findings suggest that the investigated MMP-1 and MMP-3 gene polymorphisms (1607 1G/2G and 1171 5A/6A) are not significantly associated with the risk of developing rheumatoid arthritis.
  • These specific MMP gene variations do not appear to be major genetic risk factors for RA based on current evidence.

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