Related Experiment Video
Updated: Apr 15, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
Tomohiro Inaba1, Hiromu Oura, Kana Morinaga
1Graduate School of Life and Environmental Sciences, University of Tsukuba.
Abstract:
Bacteria often thrive in natural environments through a sessile mode of growth, known as the biofilm. Biofilms are well-structured communities and their formation is tightly regulated. However, the mechanisms by which interspecies interactions alter the formation of biofilms have not yet been elucidated in detail. We herein demonstrated that a quorum-sensing signal in Pseudomonas aeruginosa (the Pseudomonas quinolone signal; PQS) inhibited biofilm formation by Streptococcus mutans. Although the PQS did not affect cell growth, biofilm formation was markedly inhibited. Our results revealed a unique role for this multifunctional PQS and also indicated its application in the development of prophylactic agents against caries-causing S. mutans.
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Biofilms
Bacterial Signaling
Inhibitors of Bacterial DNA Synthesis
Clinical Significance of Antibiotic Resistance

