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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Relationship between vascular function indexes, renal arteriolosclerosis, and renal clinical outcomes in chronic

Tamehachi Namikoshi1, Sohachi Fujimoto1, Daisuke Yorimitsu1

  • 1Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Japan.

Nephrology (Carlton, Vic.)
|April 10, 2015
PubMed

Insights

Vascular function indexes like central systolic blood pressure and cardio-ankle vascular index impact chronic kidney disease outcomes. Decreased HDL cholesterol is most linked to renal arteriolosclerosis.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Hypertension is a key driver of renal arteriolosclerosis in chronic kidney disease (CKD).
  • The relationship between vascular function indices and renal arteriolosclerosis in CKD remains under-investigated.
  • Central blood pressure and other vascular markers' impact on renal pathology needs clarification.

Purpose of the Study:

  • To investigate the association between vascular function indexes and renal arteriolosclerosis in CKD patients.
  • To determine the relationship between these vascular indices and renal clinical outcomes.
  • To identify independent risk factors for renal arteriolosclerosis.

Main Methods:

  • Cross-sectional study of CKD inpatients (≥20 years) undergoing renal biopsy.
  • Vascular function assessed via central systolic blood pressure (SBP), cardio-ankle vascular index (CAVI), and renal resistive index.
  • Renal arteriolosclerosis evaluated histologically; clinical outcomes included eGFR (creatinine/cystatin C) and albumin-creatinine ratio.

Main Results:

  • Central SBP showed a weak correlation with renal arteriolosclerosis.
  • Renal arteriolosclerosis was higher in hypertensive/hyperuricemic patients and correlated negatively with HDL cholesterol and eGFRcys.
  • CAVI demonstrated the strongest correlation with overall renal clinical outcomes, while central SBP and renal resistive index had specific correlations.

Conclusions:

  • Reduced serum HDL cholesterol is independently and strongly associated with renal arteriolosclerosis.
  • Cardio-ankle vascular index (CAVI) significantly impacts renal clinical outcomes in CKD, despite no direct link to arteriolosclerosis.
  • Vascular function plays a crucial role in CKD progression and outcomes.
Abstract

Keywords:
arteriolosclerosisblood pressurekidney diseasevascular resistancevascular stiffness

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