Bioactive terpenes from marine-derived fungi

Area of Science:

• Marine biology
• Mycology
• Natural product chemistry

Background:

• Marine-derived fungi are recognized as a rich source of novel secondary metabolites.
• Terpenoids represent a major class of these metabolites, known for their structural complexity and diverse bioactivities.
• Recent research has focused on identifying and characterizing these compounds from marine fungal origins.

Purpose of the Study:

• To review recent advancements in the field of marine-derived fungal terpenoids.
• To highlight terpenoids with significant and pronounced biological activities.
• To consolidate findings from the last five years of research in this area.

Main Methods:

• Literature review of scientific reports published in the last five years.
• Focus on studies detailing the isolation, structure elucidation, and bioactivity assessment of terpenoids from marine fungi.
• Systematic search for terpenoids exhibiting marked biological activities.

Main Results:

• Marine fungi have yielded a wide array of structurally diverse terpenoids.
• Many of these terpenoids display potent biological activities, including antimicrobial, anticancer, and anti-inflammatory effects.
• The last five years have seen a significant increase in the discovery of novel and bioactive marine fungal terpenoids.

Conclusions:

• Marine-derived fungi remain a highly promising resource for discovering novel bioactive terpenoids.
• Continued exploration of marine fungal metabolites is crucial for drug discovery and development.
• Terpenoids from marine fungi represent a valuable area for future research in natural product chemistry and pharmacology.