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Marine natural products as breast cancer resistance protein inhibitors

Lilia Cherigo1, Dioxelis Lopez2,3, Sergio Martinez-Luis4

  • 1Department of Organic Chemistry, Chemistry School, Faculty of Natural Sciences, Exact and Technology, University of Panama, Panama City P.O. Box 3366, Panama. chery826@hotmail.com.

Marine Drugs
|April 10, 2015
PubMed

Insights

Marine natural products show potential for inhibiting breast cancer resistance protein (BCRP), a key factor in cancer drug resistance. This research explores compounds that could overcome chemotherapy resistance and aid in developing new cancer therapies.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Breast cancer resistance protein (BCRP) is an ATP-binding cassette (ABC) transporter implicated in multidrug resistance (MDR) in various cancers.
  • BCRP overexpression reduces the efficacy of critical chemotherapeutic agents like topotecan, methotrexate, and doxorubicin.
  • The U.S. Food and Drug Administration recognizes BCRP as a clinically significant transporter contributing to reduced anticancer drug effectiveness.

Purpose of the Study:

  • To review and summarize research on marine natural products exhibiting BCRP inhibitory activity.
  • To explore the potential of these natural compounds in overcoming BCRP-mediated drug resistance.
  • To highlight the discovery of novel therapeutic agents and research tools for understanding ABC transporters.

Main Methods:

  • Literature review of scientific research findings.
  • Analysis of studies investigating marine natural products and their interaction with BCRP.
  • Synthesis of data on BCRP's role in drug resistance and potential inhibition strategies.

Main Results:

  • Identification of various marine natural products with demonstrated BCRP inhibitory effects.
  • Evidence suggesting that these compounds can modulate BCRP's efflux pump function.
  • Potential for these natural products to restore sensitivity to chemotherapeutic drugs.

Conclusions:

  • Marine natural products represent a promising source for developing novel BCRP inhibitors.
  • Targeting BCRP with natural compounds offers a viable strategy to combat cancer multidrug resistance.
  • Further research into these compounds can lead to new anticancer drugs and tools for transporter research.

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