Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microcomputer system for ion microscopy digital imaging and processing.

J C Olivo1, E Kahn, S Halpern

  • 1INSERM U-66, Institut Gustave Roussy, Villejuif, France.

Journal of Microscopy
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional profiling of primary prostate tumor in metastatic hormone-sensitive prostate cancer and association with clinical outcomes: correlative analysis of the E3805 CHAARTED trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Crime and Personality.

The Yale journal of biology and medicine·2011
Same author

Psychoses Complicating Other Diseases.

The Yale journal of biology and medicine·2011
Same author

Some Aspects of the Normal Personality Experiencing Disease.

The Yale journal of biology and medicine·2011
Same author

Attitudes of Medical Students Toward Psychiatry.

The Yale journal of biology and medicine·2011
Same author

[Physiological interactions: therapeutic tools in physiopathological constructions of the exophthalmic goiter, 1860-1960].

Revue d'histoire des sciences·2009
Same journal

Nanoprecipitate characterisation in NiTi and aluminium alloys: A TEM-based overview.

Journal of microscopy·2026
Same journal

BioImageIT: A novel python-based architecture for reproducible bio-image workflows.

Journal of microscopy·2026
Same journal

In operando imaging of the space-charge region in a 4H-SiC MOSCAP using STEM-EBIC.

Journal of microscopy·2026
Same journal

The future of DXA: How AI is transforming bone health diagnostics.

Journal of microscopy·2026
Same journal

The Origins of Ploem's Filter Cube: A Pandora's Box.

Journal of microscopy·2026
Same journal

The reproducibility gap in graph neural network workflows for cell dynamics: A checklist-driven case study.

Journal of microscopy·2026
See all related articles

This study introduces a new digital imaging system for analytical ion microscopy, enabling detailed chemical mapping of biological tissues at low concentrations. The system enhances biological interpretation of elemental distribution in tissues like rat thyroid.

Area of Science:

  • Analytical chemistry
  • Biological imaging
  • Microscopy

Background:

  • Analytical ion microscopy offers direct chemical distribution imaging in biological tissues.
  • Detecting low element concentrations is crucial for detailed tissue analysis.
  • Existing systems may have limitations in sensitivity or real-time processing.

Purpose of the Study:

  • To present a microcomputer-based digital imaging system for analytical ion microscopy.
  • To achieve high-sensitivity image acquisition at low light levels.
  • To enable on-line and off-line image processing for biological interpretation.

Main Methods:

  • A high-sensitivity video camera was integrated with a specialized image processor.
  • The system acquires 512 x 512 pixel images with 8-bit accuracy.

Related Experiment Videos

  • Real-time and off-line image processing software was implemented.

    • Main Results:

    • The digital imaging system demonstrated effective low light level acquisition.
    • On-line processing allowed for immediate feedback and adjustments.
    • Off-line manipulation facilitated detailed correlation for biological interpretation.

    Conclusions:

    • The developed digital imaging system is a powerful tool for analytical ion microscopy.
    • It enables precise elemental mapping in biological tissues, even at low concentrations.
    • The system's capabilities were validated through iodine mapping in rat thyroid tissue.