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Associations between pentraxin 3 and severity of coronary artery disease
Hua Liu1, Shaofeng Guan1, Weiyi Fang1
1Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Insights
Plasma pentraxin 3 (PTX3) levels correlate with coronary artery lesion severity. PTX3 is significantly associated with coronary artery stenosis in patients with chronic kidney disease.
Area of Science:
- Cardiology
- Biomarkers
- Renal Medicine
Background:
- Coronary artery disease (CAD) poses a significant health burden.
- Inflammatory markers are crucial in understanding CAD.
- Pentraxin 3 (PTX3) and C-reactive protein (CRP) are key inflammatory markers.
Purpose of the Study:
- To investigate the association between plasma PTX3 and CRP levels and the severity of coronary artery lesions.
- To evaluate PTX3 and CRP as potential biomarkers for coronary artery disease (CAD) severity.
Main Methods:
- 60 patients with coronary heart disease (CHD) undergoing coronary angiography (CAG) were enrolled.
- Coronary artery lesion severity was quantified using the Gensini score.
- Plasma PTX3 and CRP levels were measured and analyzed against Gensini scores.
Main Results:
- A significant positive linear correlation was found between plasma PTX3 levels and the Gensini score (r=0.513, p<0.001).
- PTX3 levels were significantly higher in patients with higher Gensini scores.
- PTX3 levels were significantly associated with Gensini score in patients with chronic renal dysfunction (p=0.012), unlike CRP.
Conclusions:
- Plasma PTX3 levels are positively associated with the severity of coronary artery lesions.
- PTX3 may serve as a valuable biomarker for coronary artery stenosis, particularly in patients with chronic renal dysfunction.
Objective:
To investigate the associations between plasma levels of pentraxins 3 (PTX3) and C reactive protein (CRP) and the severity of coronary artery lesions.
Design And Methods:
60 patients with coronary heart disease (CHD) who underwent coronary angiography (CAG) in our hospital were included. Plasma was collected during CAG. The coronary Gensini score was used to evaluate the severity of coronary artery lesions. Associations between Gensini scores and plasma levels of PTX3 and CRP were analysed. Patients with estimated glomerular filtration rate <60 mL/min/1.73 m(2) were included in the chronic renal dysfunction subgroup.
Results:
A linear correlation was observed between PTX3 and the Gensini score (r=0.513, p<0.001). One-way analysis of variance showed that PTX3 levels were significantly higher in patients with Gensini scores >90 compared with patients with scores of 46-90 or <45 (0-45:4.8±0.8, 46-90:6.7±1.2, >90:7.7±2.0, p<0.001). Stepwise multiple linear regression showed that PTX3 levels were significantly associated with Gensini score in patients with chronic renal dysfunction (p=0.012), while no significant association was found for CRP.
Conclusions:
PTX3 levers were positively associated with the severity of coronary artery lesions. PTX3 is closely associated with the severity of coronary artery stenosis in patients with chronic renal dysfunction.
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