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Prediction of HIV Virologic Failure Among Adolescents Using the Pediatric Symptom Checklist
Elizabeth D Lowenthal1,2, Tafireyi Marukutira3, Ontibile Tshume3
1Departments of Pediatrics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. lowenthale@email.chop.edu.
Abstract:
Psychosocial dysfunction is a risk factor for treatment non-adherence among children and adolescents. A previous study showed that high scores on the Pediatric Symptom Checklist (PSC) were associated with a history of HIV virologic failure. We assessed whether high scores on the PSC could predict virologic failure in HIV-infected youth. Caregivers of 234 adolescents between the ages of 10 and 16 years were asked to complete a PSC at baseline. Elevated PSC scores were associated with virologic failure in the subsequent 6 months. PSC scores may help guide resource utilization when viral load monitoring is limited.
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