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Updated: Apr 15, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin
Marco Demaria1, Pierre Yves Desprez2, Judith Campisi3
1Campisi Laboratory, Buck Institute for Research on Aging, Novato, California, USA.
Abstract:
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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