Related Experiment Video
Updated: Apr 15, 2026
Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
Post-transplant liver function score as an early surrogate marker of long-term outcome
Mazen Hassanain1, Eve Simoneau2, Ahmad Madkhali1
1Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
Background:
Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings.
Material And Methods:
In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
Results:
In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
Conclusions:
PTLF score shows promise as an early surrogate marker of post-orthotopic liver transplantation mortality and morbidity by providing results within the first 7 days post-transplantation. PTLF score can potentially be used as a tool to assess the impact of perioperative interventions by predicting long-term outcomes early in the clinical course of transplant patients.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:28Kidney Transplant I: Introduction
01:16Kidney Transplant III: Nursing Management