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Updated: Apr 15, 2026

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes

Published on: October 10, 2020

Long noncoding RNAs in cardiac development and ageing.

Yvan Devaux¹, Jennifer Zangrando¹, Blanche Schroen²

¹Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.

Nature Reviews. Cardiology

|April 10, 2015

Summary

This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial epigenetic regulators in the mammalian genome. This review details their roles in cardiac development, ageing, and potential as therapeutic targets.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Last Updated: Apr 15, 2026

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes

Published on: October 10, 2020

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

Genomics
Epigenetics
Cardiovascular Biology

Background:

Mammalian genomes extensively transcribe noncoding RNAs, with long noncoding RNAs (lncRNAs) emerging as key epigenetic regulators.
lncRNAs employ diverse mechanisms to modulate gene expression, influencing cellular and tissue functions.
These molecules play significant roles in both healthy and diseased hearts.

Purpose of the Study:

To review current knowledge on the functions of lncRNAs in cardiac development and ageing.
To elucidate the mechanisms by which lncRNAs regulate gene expression.
To explore the therapeutic and biomarker potential of lncRNAs in cardiac contexts.

Main Methods:

Literature review and synthesis of existing research on lncRNAs in the heart.
Classification and definition of lncRNAs.
Analysis of lncRNA-mediated gene regulation, focusing on chromatin remodeling.

Main Results:

lncRNAs are critical regulators of embryonic stem cell differentiation and cardiac cell fate.
lncRNAs significantly influence cardiac development and the ageing process.
Chromatin remodeling is a key mechanism through which lncRNAs exert their regulatory functions in the heart.

Conclusions:

lncRNAs are integral to cardiac biology, impacting development, ageing, and disease.
Understanding lncRNA mechanisms offers insights into cardiac health and pathology.
lncRNAs hold promise as novel therapeutic targets and biomarkers for cardiovascular conditions.