Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.7K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.7K
Fibril-associated Collagen01:11

Fibril-associated Collagen

3.8K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.8K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

3.5K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.5K
Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

8.5K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Reported Human Cases of Urolithin A Renal Calculi.

Kidney international reports·2026
Same author

Computational methods for inertial microfluidics: recent advances and future perspectives.

Microsystems & nanoengineering·2025
Same author

Treatment with lipoxin A<sub>4</sub> improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2024
Same author

Treatment with lipoxin A 4 improves influenza A infection outcome through macrophage reprogramming, anti-inflammatory and pro-resolutive responses.

Research square·2024
Same author

Numerical investigation of heterogeneous soft particle pairs in inertial microfluidics.

Soft matter·2024
Same author

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.

JCI insight·2023

Related Experiment Video

Updated: Apr 15, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.9K

Activity-dependent differences in function between proximal and distal Schaffer collaterals.

Benjamin Owen1, Lawrence M Grover2

  • 1Department of Pharmacology, Physiology and Toxicology, Marshall University, School of Medicine, Huntington, West Virginia.

Journal of Neurophysiology
|April 10, 2015
PubMed
Summary

High-frequency stimulation affects Schaffer collateral axon excitability differently in proximal and distal regions. This study reveals distinct responses to stimulation patterns, suggesting a mechanism for filtering neural activity.

Keywords:
Schaffer collateralaction potentialburst stimulationhigh-frequency stimulationhyperexcitability

More Related Videos

Author Spotlight: Isolation of Long Muscle Fibers from Mouse Hindlimb Muscles for Studying Excitation-Contraction Coupling Across Fiber Types
08:12

Author Spotlight: Isolation of Long Muscle Fibers from Mouse Hindlimb Muscles for Studying Excitation-Contraction Coupling Across Fiber Types

Published on: December 1, 2023

4.1K
Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS
05:25

Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS

Published on: June 7, 2024

1.9K

Related Experiment Videos

Last Updated: Apr 15, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.9K
Author Spotlight: Isolation of Long Muscle Fibers from Mouse Hindlimb Muscles for Studying Excitation-Contraction Coupling Across Fiber Types
08:12

Author Spotlight: Isolation of Long Muscle Fibers from Mouse Hindlimb Muscles for Studying Excitation-Contraction Coupling Across Fiber Types

Published on: December 1, 2023

4.1K
Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS
05:25

Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS

Published on: June 7, 2024

1.9K

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Axonal Physiology

Background:

  • Axon conduction fidelity is crucial for neural signal transmission.
  • Previous studies showed varied responses of Schaffer collateral axons to high-frequency stimulation (HFS).

Purpose of the Study:

  • To investigate proximal and distal Schaffer collateral responses to HFS and burst stimulation.
  • To compare excitability changes in different axonal regions during various stimulation patterns.

Main Methods:

  • Used whole-cell and dual-field-potential recordings in hippocampal slices.
  • Applied high-frequency stimulation (10-100 Hz) and burst stimulation (100-1,000 ms intervals).
  • Recorded from both proximal (CA3) and distal (CA1) regions of Schaffer collaterals.

Main Results:

  • HFS induced frequency-dependent excitability changes.
  • Proximal axons showed stronger depression, while distal axons exhibited an initial excitability increase.
  • Burst stimulation mimicked HFS effects, with shorter intervals causing more pronounced changes and regional differences.

Conclusions:

  • Functional differences exist between proximal and distal Schaffer collaterals.
  • These differences may enable selective filtering of non-physiological activity.
  • This mechanism could optimize the conduction of physiological activity across extensive axonal arbors.