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Updated: Apr 15, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Cathodoluminescence-activated nanoimaging: noninvasive near-field optical microscopy in an electron microscope
Connor G Bischak, Craig L Hetherington, Zhe Wang1
1⊥Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States.
Abstract:
We demonstrate a new nanoimaging platform in which optical excitations generated by a low-energy electron beam in an ultrathin scintillator are used as a noninvasive, near-field optical scanning probe of an underlying sample. We obtain optical images of Al nanostructures with 46 nm resolution and validate the noninvasiveness of this approach by imaging a conjugated polymer film otherwise incompatible with electron microscopy due to electron-induced damage. The high resolution, speed, and noninvasiveness of this "cathodoluminescence-activated" platform also show promise for super-resolution bioimaging.
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