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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Lower-limb performance disparities: implications for exercise prescription in multiple sclerosis.

Rebecca D Larson, Kevin K McCully, Daniel J Larson

    Journal of Rehabilitation Research and Development
    |April 10, 2015
    PubMed
    Summary

    Individuals with multiple sclerosis (MS) show leg performance differences during cycling. Stronger legs performed more work than weaker legs, unlike in controls, indicating a need for tailored exercise programs.

    Keywords:
    MSbilateralexercise prescriptionleg performanceleg performance disparitieslower limblower-limb exercisemultiple sclerosismusclework

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    Area of Science:

    • Neurology
    • Exercise Physiology
    • Rehabilitation Science

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease affecting motor function.
    • Unilateral exercise performance can reveal subtle functional deficits.
    • Standard exercise testing may not capture limb-specific impairments in MS.

    Purpose of the Study:

    • To investigate exercise tolerance and performance disparities between legs in individuals with MS during unilateral cycling.
    • To compare limb performance in MS patients with that of healthy controls.

    Main Methods:

    • Eight individuals with relapsing-remitting MS and seven healthy controls participated.
    • Participants completed submaximal, fixed-load, single-leg cycling tests.
    • Work output was measured for each leg to quantify performance.

    Main Results:

    • Individuals with MS demonstrated significantly greater work output with their stronger leg compared to their weaker leg (p=0.02).
    • The control group showed no significant difference in work output between their legs (p=0.36).

    Conclusions:

    • Legs in individuals with MS exhibit performance inequalities during unilateral exercise.
    • These findings underscore the importance of individualized exercise assessments for prescribing rehabilitation programs in MS.
    • Tailored training strategies may be necessary to address limb-specific deficits in MS patients.