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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Apr 15, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Seeking a roadmap toward neuroepigenetics.

Jaehoon Shin¹, Guo-li Ming², Hongjun Song³

¹Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

|April 10, 2015

Summary

This summary is machine-generated.

Scientists analyzed vast genomic data from human tissues and cells to uncover functional regulatory elements. This research will advance neuroepigenetics by revealing novel insights into brain function and disease.

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Area of Science:

Genomics
Neuroscience
Epigenetics

Background:

Investigating functional regulatory elements in the human genome is crucial for understanding gene expression.
Large-scale genomic datasets offer unprecedented opportunities to explore complex biological systems.

Purpose of the Study:

To determine the potential neuroscientific insights obtainable from extensive genomic data.
To explore the impact of functional genomic elements on the future direction of neuroepigenetics.

Main Methods:

Analysis of large-scale genomic data from human tissue samples and cell lines.
Identification and characterization of functional regulatory elements within the genome.

Main Results:

The study identified key functional regulatory elements with potential implications for neurological processes.
The findings provide a foundation for understanding how genomic regulation influences brain function.

Conclusions:

Genomic regulatory elements hold significant potential for advancing neuroepigenetics research.
This data will guide future studies on the genetic basis of neurological disorders and brain function.