Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A three-groups non-local model for combining heterogeneous data sources to identify genes associated with Parkinson's disease.

Biometrics·2026

Same author

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification.

bioRxiv : the preprint server for biology·2026

Same author

Survey of the human proteostasis network: the ubiquitin-proteasome system.

bioRxiv : the preprint server for biology·2026

Same author

Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains.

bioRxiv : the preprint server for biology·2026

Same author

Discovery and Characterization of Zelnecirnon (RPT193), a Potent and Selective CCR4 Antagonist for Allergic Disorders.

Journal of medicinal chemistry·2026

Same author

A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease.

Nature neuroscience·2025

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

Cell-based screening: extracting meaning from complex data.

Steven Finkbeiner¹, Michael Frumkin², Paul D Kassner³

¹Director of the Taube/Koret Center for Neurodegenerative Disease and the Hellman Family Foundation Program in Alzheimer's Disease Research, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.

|April 10, 2015

Summary

This summary is machine-generated.

Unbiased discovery methods offer new insights into central nervous system (CNS) diseases. Advances in imaging and computational tools are improving data analysis to guide future therapy development.

More Related Videos

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Related Experiment Videos

Last Updated: Apr 15, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Area of Science:

Neurobiology
Pharmacology
Medical Imaging

Background:

Unbiased discovery approaches are crucial for understanding central nervous system (CNS) diseases.
Identifying novel therapeutic targets requires innovative research strategies.

Purpose of the Study:

To review lessons learned from imaging-based screening in CNS disease research.
To highlight recent advances in computational tools for data synthesis and knowledge discovery.

Main Methods:

Review of imaging-based screening methodologies.
Analysis of computational tools for big data synthesis in neurobiology.

Main Results:

Imaging-based screening provides valuable neurobiological insights.
Advanced computational tools enhance the interpretation of complex screening data.

Conclusions:

Unbiased discovery approaches, particularly those using advanced imaging and computational methods, are vital for advancing CNS disease research.
These integrated strategies can reliably guide the development of novel therapies for neurological disorders.