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Anticardiolipin Antibodies in Children with Helicobacter pylori Infection

Serdar Umit Sarıcı1, Orhan Gursel1, Emin Kurekci1

  • 1Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.

Helicobacter
|April 10, 2015
PubMed

Insights

Helicobacter pylori infection in children is linked to anticardiolipin (aCL) antibodies, which are associated with thrombosis. Eradicating H. pylori effectively reduces these aCL antibodies, suggesting a causal relationship.

Area of Science:

  • Pediatric autoimmune disorders
  • Infectious disease immunology
  • Thrombosis and hemostasis

Background:

  • Anticardiolipin (aCL) antibodies are linked to thrombotic events like stroke and myocardial infarction.
  • Helicobacter pylori (H. pylori) infection is implicated in various diseases, including autoimmune conditions.
  • A potential association between H. pylori infection and aCL antibodies warrants investigation, particularly in pediatric populations.

Purpose of the Study:

  • To investigate the prevalence of aCL antibody positivity in children with H. pylori infection.
  • To explore the relationship between H. pylori infection and anticardiolipin antibody levels.
  • To assess the impact of H. pylori eradication therapy on aCL antibody levels in children.

Main Methods:

  • Studied anticardiolipin antibody levels in 84 pediatric patients before and after H. pylori eradication therapy.
  • Included a control group of 40 children for comparison.
  • Measured aCL IgA, IgM, and IgG antibody levels using standardized assays.

Main Results:

  • Pre-treatment aCL antibody levels (IgA, IgM, IgG) in children with H. pylori infection were significantly higher compared to post-treatment levels and controls.
  • Post-treatment aCL antibody levels in the study group were not significantly different from those in the control group.
  • Successful eradication of H. pylori led to a significant decrease in anticardiolipin antibody titers.

Conclusions:

  • H. pylori infection can induce anticardiolipin antibody positivity in children.
  • Eradication of H. pylori infection results in the disappearance of anticardiolipin antibodies.
  • This suggests a causal link between H. pylori and aCL antibody production in pediatric patients.
Abstract

Keywords:
H. pylorianticardiolipin antibodieschildren

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