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Updated: Apr 15, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Surface characterization and drug release from porous microparticles based on methacrylic monomers and xanthan
Maria-Andreea Lungan1, Marcel Popa2, Stefania Racovita3
1"Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, Prof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050, Iasi, Romania; "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania.
Abstract:
Porous crosslinked microparticles based on glycidyl methacrylate and xanthan were prepared by suspension polymerization and used for loading theophylline, a bronhodilatator drug, in order to obtain new drug delivery systems. The surface morphologies observed by means of SEM and AFM analysis demonstrated that microparticles show a spherical shape and are characterized by a porous structure. The presence of xanthan in the structure of microparticles leads to a decrease of surface roughness and pore diameters as well as to an increase of hydrophilicity degree compared to the micropaticles based only on glycidyl methacrylate. To analyze the in vitro release data various mathematical models were used, such as, first order, Higuchi model, Korsmeyer-Peppas model and Baker-Lonsdale model. Based on the highest values of the correlation coefficient, the analysis of the kinetic data indicate that drug release from G1 and X1 porous microparticles fits similarly well to the first order and Higuchi models and diffusion was the dominant mechanism of drug release.
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