Related Experiment Video
Updated: Apr 15, 2026
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
[Establishment of animal model with peri-implantitis after immediate implantation in rabbits]
Lan-Hua Shen1, Ling-Na Meng, Xin Wang
1Department of Stomatology, Nangang Branch, Heilongjiang Provincial Hospital. Haerbin 150001, Heilongjiang Province, China.E-mail:1347755247@qq.com.
Purpose:
To establish animal model with peri-implantitis after immediate implantation and study bone defect characteristics by Micro-CT.
Methods:
Implants were immediately planted in the first mandibular anterior tooth of 12 rabbits. Silk ligatures were placed around one side of the implants to induce peri-implantitis. Micro-CT was used to evaluate bone defect at different periods after implantation.
Results:
Silk ligatures around the implants were effective to induce peri-implantitis. With the development of peri-implantitis, implants can not be well integrated with bone. Bone defect was gradually produced and then aggravated, and finally formed typical "V-type" bone defect.
Conclusions:
The establishment of animal model with peri-implantitis is simple and effective, which provides important references for relative studies in the field of peri-implantitis.
