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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Apr 15, 2026

Analysis of Zebrafish Kidney Development with Time-lapse Imaging Using a Dissecting Microscope Equipped for Optical Sectioning
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Wilms' tumor 1 (WT1) protein expression in human developing tissues.

Rosalba Parenti1, Lucia Salvatorelli2, Giuseppe Musumeci3

  • 1Department of Biomedical and Biotechnological Sciences, Physiology Section, School of Medicine, University of Catania, Catania, Italy.

Acta Histochemica
|April 11, 2015
PubMed
Summary

The Wilms tumor 1 (WT1) gene plays a dual role in human development and cancer. Understanding WT1 protein expression during development may reveal new therapeutic strategies for cancer.

Keywords:
DevelopmentHumanImmunohistochemistryOncofetalWT1

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Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Molecular Oncology

Background:

  • The Wilms tumor 1 (WT1) gene is critical for human development.
  • WT1 exhibits context-dependent roles as an oncogene or tumor suppressor.
  • WT1 protein's dynamic expression during development is key to understanding its oncogenic functions.

Purpose of the Study:

  • To review the dynamic immunohistochemical expression and distribution of WT1 protein during human ontogenesis.
  • To explore the potential of WT1 developmental expression patterns for cancer research.
  • To discuss WT1's role in cancerogenesis and potential therapeutic applications.

Main Methods:

  • Review of existing literature on WT1 immunohistochemical expression in human developmental tissues.
  • Analysis of illustrations and findings on WT1 protein distribution.
  • Discussion of the implications of WT1 nuclear/cytoplasmic expression in tumors.

Main Results:

  • WT1 protein shows dynamic expression patterns throughout human development.
  • Specific WT1 expression profiles in developmental tissues are identified.
  • The review highlights correlations between developmental expression and tumor characteristics.

Conclusions:

  • WT1's role in human development is closely linked to its function in cancer.
  • Understanding WT1's developmental regulation offers insights into its oncogenic or tumor-suppressive activities.
  • WT1 immunohistochemistry in tumors may reflect its normal developmental roles, guiding therapeutic strategies.