Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

5.9K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.9K
Conjugated Proteins02:50

Conjugated Proteins

29.9K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
29.9K
RNA Editing02:23

RNA Editing

10.2K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
10.2K
Immunoprecipitation01:20

Immunoprecipitation

8.1K
Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
8.1K
The ADP/ATP Carrier Protein01:42

The ADP/ATP Carrier Protein

4.7K
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitrate contamination in a karst aquifer affected by acid mine drainage during a storm event: Insights from stable isotopes and hydrochemical tracers.

Journal of hazardous materials·2026
Same author

Optimized functional zoning based on land use carbon emissions and carbon balance: a case study in Shaanxi Province, China.

Carbon balance and management·2026
Same author

Microalgae-based biogas slurry treatment integrated with sustainable aviation fuel production: from waste to high-value bio-jet fuel.

Bioresource technology·2026
Same author

Volatile self-selective memristive neuron for millisecond-latency neuromorphic object detection at the edge.

Nature communications·2026
Same author

Exploring the Mechanism of Tannic Acid Against <i>Pichia kudriavzevii</i> in the VK2/E6E7 Vaginal Epithelial Cell Line and Its Synergy with Azoles on Drug-Resistant <i>Candida</i> Species.

Pathogens (Basel, Switzerland)·2026
Same author

Nanocomposite scaffolds incorporating ginsenoside Rg1-loaded ZIF-8 nanoparticles for enhanced osteogenesis and bone regeneration.

Journal of translational medicine·2026

Related Experiment Video

Updated: Apr 15, 2026

Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development
12:53

Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development

Published on: March 16, 2022

2.3K

Apolipoprotein M.

Kun Ren1, Zhen-Li Tang1, Yue Jiang1

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001 Hunan Province, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 11, 2015
PubMed
Summary
This summary is machine-generated.

Apolipoprotein M (ApoM) is a protein influencing HDL function and lipid binding. Research explores its expression regulation and potential therapeutic roles in diabetes by modulating glucose and insulin levels.

Keywords:
Apolipoprotein MFunctionRegulation

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
09:45

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Published on: May 18, 2021

2.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development
12:53

Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development

Published on: March 16, 2022

2.3K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
09:45

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Published on: May 18, 2021

2.6K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Apolipoprotein M (ApoM) is a plasma protein primarily associated with high-density lipoproteins (HDLs).
  • Its expression is regulated by various transcription factors and signaling molecules.
  • ApoM binds functional lipids like Sphingosine-1-Phosphate (S1P).

Purpose of the Study:

  • To review the characteristics of Apolipoprotein M (ApoM).
  • To elucidate the regulatory mechanisms of ApoM expression.
  • To summarize the functional roles of ApoM, including its impact on HDL and glucose metabolism.

Main Methods:

  • Literature review of studies on Apolipoprotein M (ApoM).
  • Analysis of factors influencing ApoM gene expression (transcriptional and post-transcriptional).
  • Examination of ApoM's structural and functional properties, including lipid binding and effects on HDL.

Main Results:

  • Multiple factors like HNF-1α, 4α, LRH-1, and Foxa2 upregulate ApoM expression.
  • Receptors such as LXR, RXR, FXR, and SHP, along with cytokines, downregulate ApoM expression.
  • ApoM facilitates preβ-HDL formation, exerts atheroprotective effects, and may improve glucose control and insulin secretion in diabetes.

Conclusions:

  • Apolipoprotein M (ApoM) plays a significant role in HDL functionality and lipid metabolism.
  • Understanding ApoM expression regulation is crucial for its therapeutic potential.
  • ApoM augmentation shows promise for managing diabetes by improving glycemic control and insulin secretion.