Related Experiment Video

Updated: Apr 15, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

13.2K

[Subcutaneous phaeohyphomycosis caused by Phaeoacremonium parasiticum]

Jose Alayeto Ortega1, Albert Alier Fabregó2, Lluis Puig Verdie2

  • 1Servicio de Microbiología, Hospital Sant Joan de Déu, Barcelona, España.

Revista Iberoamericana De Micologia
|April 11, 2015
PubMed
Abstract

Insights

Dematiaceous fungal infections, like phaeohyphomycosis, can affect immunocompromised individuals. This report details two Spanish cases of Phaeoacremonium parasiticum infections, one requiring combination therapy.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Dematiaceous fungi cause infections, primarily in immunocompromised patients.
  • These infections range from localized subcutaneous to life-threatening disseminated forms.
  • Traumatic inoculation is a common route, often leading to slower infection progression.

Observation:

  • Two cases of phaeohyphomycosis caused by Phaeoacremonium parasiticum are presented.
  • Case 1: A cancer patient with subcutaneous lesions on the left hand and forearm.
  • Case 2: A patient with subcutaneous abscesses on the left leg.

Findings:

  • Phaeoacremonium parasiticum infections were confirmed in Spain.
  • Successful treatment in the second case involved amphotericin B lipid complex, posaconazole, and surgical resections.
  • Phaeohyphomycosis can manifest as localized subcutaneous disease.

Implications:

  • Highlights the presence and clinical significance of Phaeoacremonium parasiticum in Spain.
  • Demonstrates the potential need for aggressive combination therapy, including antifungals and surgery, for phaeohyphomycosis.
  • Emphasizes the importance of considering dematiaceous fungal infections in immunocompromised patients with subcutaneous lesions.
Keywords:
Feohifomicosis subcutáneaKidney transplantPhaeoacremonium parasiticumSubcutaneous phaeohyphomycosisTrasplante renal

More Related Videos

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes08:34

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

9.3K
Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus12:29

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus

Published on: April 19, 2017

10.8K

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
754
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.3K
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
2.5K
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
2.1K
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
2.2K
Bacterial Phylum Planctomycetes01:26

Bacterial Phylum Planctomycetes

Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
553