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Hereditary systemic immunoglobulin light-chain amyloidosis.

Merrill D Benson1, Juris J Liepnieks2, Barbara Kluve-Beckerman2

  • 1Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, Indianapolis, IN: and Richard L. Roudebush VA Medical Center, Indianapolis, IN.

Blood
|April 11, 2015
PubMed
Summary

A novel hereditary amyloidosis, caused by a specific mutation in the immunoglobulin kappa light chain gene (Ser131Cys), leads to renal failure. This genetic form of amyloid light-chain amyloidosis can be misdiagnosed, highlighting the need for accurate genetic testing.

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