The Choice of Renal Replacement Therapy (CORETH) project: study design and methods
Related Experiment Video
Updated: Apr 15, 2026

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
Maxi Robinski1, Wilfried Mau1, Juliane Lamprecht1
1Institute for Rehabilitation Medicine , Medical Faculty of the Martin-Luther-University Halle-Wittenberg , Halle (Saale) , Germany.
Insights
This study investigates how psychosocial and cognitive factors influence the choice between peritoneal dialysis and haemodialysis. Understanding these patient conditions can improve shared decision-making in renal replacement therapy.
Area of Science:
- Nephrology
- Psychology
- Health Economics
Background:
- Limited research exists on the impact of psychosocial and cognitive factors on dialysis modality selection.
- The Choice of Renal Replacement Therapy (CORETH) study addresses this gap by examining these patient conditions.
Purpose of the Study:
- To investigate the influence of psychosocial and cognitive factors on the choice between peritoneal dialysis and haemodialysis.
- To analyze shared decision-making aspects in renal replacement therapy selection.
- To provide an economic evaluation of treatment costs.
Main Methods:
- A multicentre study involving approximately 1200 participants from 50 dialysis centers across Germany.
- Patients are categorized based on their chosen permanent dialysis modality (peritoneal or haemodialysis).
- Data collection includes questionnaires on social, psychological, and shared decision-making factors, alongside cognitive function testing and a one-year follow-up for cost analysis.
Main Results:
- Results will illuminate treatment choices within the German healthcare system.
- The study will offer insights into patient autonomy discussions.
- Findings aim to enhance patient participation in health-related decision-making.
Conclusions:
- Understanding patient psychosocial and cognitive states is crucial for informed dialysis modality selection.
- The CORETH study design facilitates a comprehensive analysis of factors influencing renal replacement therapy choice.
- Results are expected to empower patients in their healthcare decisions and inform policy within the German healthcare system.
Background:
To date, research has neglected the patient's psychosocial and cognitive conditions as contributing factors to dialysis modality decision-making. Hence, the Choice of Renal Replacement Therapy (CORETH) study aims to examine these conditions with regard to their impact on the choice. Here we describe the design of the multicentre study, which is supported by a grant from the German Ministry for Education and Research.
Methods:
Two groups of patients will be compared after having chosen peritoneal or haemodialysis as permanent treatment. About 1200 participants from 50 dialysis centres all over Germany will be questioned. The questionnaire addresses social, psychological and shared decision-making aspects. Furthermore, cognitive functioning will be tested. For an economic evaluation direct and indirect costs of treatment will be calculated. Changes will be examined through a one-year follow-up.
Conclusions:
The results will enlighten the treatment choice under the German healthcare system. They will provide further insight regarding the discussion on patient autonomy. From the patients' perspective, the results will help to strengthen their participation in the individual process of health-related decision-making.
Related Concept Videos
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Kidney Transplant I: Introduction
Acute Kidney Injury V: Interprofessional Care
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Chronic Kidney Disease III: Interprofessional Care

