Related Experiment Video
Updated: Apr 15, 2026

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
The Choice of Renal Replacement Therapy (CORETH) project: study design and methods
Maxi Robinski1, Wilfried Mau1, Juliane Lamprecht1
1Institute for Rehabilitation Medicine , Medical Faculty of the Martin-Luther-University Halle-Wittenberg , Halle (Saale) , Germany.
This study investigates how psychosocial and cognitive factors influence the choice between peritoneal dialysis and haemodialysis. Understanding these patient conditions can improve shared decision-making in renal replacement therapy.
Area of Science:
- Nephrology
- Psychology
- Health Economics
Background:
- Limited research exists on the impact of psychosocial and cognitive factors on dialysis modality selection.
- The Choice of Renal Replacement Therapy (CORETH) study addresses this gap by examining these patient conditions.
Purpose of the Study:
- To investigate the influence of psychosocial and cognitive factors on the choice between peritoneal dialysis and haemodialysis.
- To analyze shared decision-making aspects in renal replacement therapy selection.
- To provide an economic evaluation of treatment costs.
Main Methods:
- A multicentre study involving approximately 1200 participants from 50 dialysis centers across Germany.
- Patients are categorized based on their chosen permanent dialysis modality (peritoneal or haemodialysis).
- Data collection includes questionnaires on social, psychological, and shared decision-making factors, alongside cognitive function testing and a one-year follow-up for cost analysis.
Main Results:
- Results will illuminate treatment choices within the German healthcare system.
- The study will offer insights into patient autonomy discussions.
- Findings aim to enhance patient participation in health-related decision-making.
Conclusions:
- Understanding patient psychosocial and cognitive states is crucial for informed dialysis modality selection.
- The CORETH study design facilitates a comprehensive analysis of factors influencing renal replacement therapy choice.
- Results are expected to empower patients in their healthcare decisions and inform policy within the German healthcare system.
Related Concept Videos
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Kidney Transplant I: Introduction
Acute Kidney Injury V: Interprofessional Care
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Chronic Kidney Disease III: Interprofessional Care

