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Updated: Apr 15, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Clinicopathologic features of 112 cases with mantle cell lymphoma
Dong-Mei Zhou1, Gang Chen1, Xiong-Wei Zheng1
1Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
Objective:
This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).
Methods:
Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.
Results:
All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.
Conclusion:
MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
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