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[Myocardial asynergy of the left ventricle in patients with aortic stenosis]

Iu D Volynskiĭ, V V Goloma, A I Kurochkina

    Kardiologiia
    |August 1, 1989
    PubMed

    Insights

    This study analyzed left ventricular function in patients with aortic stenosis, identifying distinct functional areas and their abnormal movements. Findings highlight the varied responses of the left ventricle to increased workload.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Physiology

    Background:

    • Left ventricular (LV) function is crucial for cardiovascular health.
    • Aortic stenosis (AS) imposes significant systolic overload on the LV.
    • Understanding LV regional dynamics in AS is essential for patient assessment.

    Purpose of the Study:

    • To define normal systolic and diastolic pulse values for three functional areas of the left ventricle.
    • To quantitatively assess hypokinesis and hyperkinesis in these functional areas.
    • To investigate left ventricular cinematics in patients with aortic stenosis.

    Main Methods:

    • Analysis of left ventriculograms from 21 healthy individuals using the correlation method.
    • Quantitative determination of hypokinesis and hyperkinesis in defined LV functional areas.
    • Study of left ventricular cinematics in 105 patients with aortic stenosis.

    Main Results:

    • Normal systolic and diastolic pulse values were established for three LV functional areas.
    • Regional cinematic abnormalities were prevalent in patients with aortic stenosis.
    • Hypokinesis was detected in 62% of AS patients, hyperkinesis in the upper areas in 33%, and normal dynamics in 7%.

    Conclusions:

    • Left ventricular response to systolic overload in aortic stenosis is heterogeneous.
    • Abnormal regional wall motion (hypokinesis/hyperkinesis) is common in aortic stenosis.
    • Consideration of these heterogeneous LV responses is vital for clinical and prognostic assessments in AS.

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