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Emotion-motion interactions in conversion disorder: an FMRI study.

Selma Aybek1, Timothy R Nicholson2, Owen O'Daly3

  • 1Section of Cognitive Neuropsychiatry, King's College London, Institute of Psychiatry, London, SE5 8AF, United Kingdom; Laboratory for Behavioral Neurology and Imaging of Cognition, Fundamental Neurosciences, Geneva University, Rue Michel-Servet 1, 1211, Genève, Switzerland.

Plos One
|April 11, 2015
PubMed
Summary
This summary is machine-generated.

Motor conversion disorder (CD) patients show heightened brain responses to negative emotions, particularly fear. This emotional dysregulation may link to motor dysfunction in CD.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Motor conversion disorder (CD) is characterized by neurological symptoms inconsistent with established medical explanations.
  • The neural underpinnings of emotional processing in CD remain incompletely understood.

Purpose of the Study:

  • To investigate the neural correlates of implicit negative emotion processing in motor conversion disorder.
  • To compare brain activity in response to emotional stimuli between CD patients and healthy controls.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • 12 motor CD patients and 14 healthy controls viewed standardized facial stimuli expressing fear, sadness, or neutral emotions.
  • Temporal changes in stimulus sensitivity were modeled.

Main Results:

  • CD patients exhibited increased amygdala activation to negative emotions compared to controls.
  • Enhanced activation was observed in CD patients within the periaqueductal grey matter (freeze response), cingulate gyrus, and supplementary motor area.
  • Increased response amplitude to fearful stimuli persisted over time in CD patients.

Conclusions:

  • CD patients demonstrate abnormal emotional regulation, specifically a failure of habituation or sensitization to negative stimuli.
  • Elevated activation in midbrain and frontal areas suggests an aberrant behavioral-motor response to threat in CD.
  • These findings propose a mechanism linking emotional dysregulation to motor dysfunction in conversion disorder.