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Published on: September 7, 2022
Preexisting cognitive impairment is associated with postoperative cognitive dysfunction after hip joint replacement
Brendan Silbert1, Lisbeth Evered, David A Scott
1From the Centre for Anaesthesia and Cognitive Function, Department of Anaesthesia, St. Vincent's Hospital, Melbourne, Victoria, Australia (B.S., L.E., D.A.S.); Anaesthesia, Perioperative and Pain Medicine Unit, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia (B.S., L.E., D.A.S.,); Department of Surgery, Monash University, Melbourne, Victoria, Australia (S.M.); Malabar Orthopaedic Clinic, Windsor, Victoria, Australia (S.M.); Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia (P.C.); Department of Orthopaedics, St. Vincent's Hospital, Melbourne, Victoria, Australia (P.C.); Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia (D.A.); National Aging Research Institute, Parkville, Victoria, Australia (D.A.); Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia (P.M.); and School of Population Health, University of Adelaide, Adelaide, South Australia, Australia (K.J.).
Preexisting cognitive impairment (PreCI) in elderly surgical patients significantly increases their risk of developing postoperative cognitive dysfunction (POCD) and long-term cognitive decline. PreCI is a strong predictor of these adverse outcomes.
Area of Science:
- Geriatric Medicine
- Neuropsychology
- Surgical Outcomes
Background:
- Cognitive impairment is a concern in elderly patients undergoing noncardiac surgery.
- Preoperative cognitive status may influence postoperative outcomes.
- Long-term cognitive changes after surgery require investigation.
Purpose of the Study:
- To determine the prevalence of preoperative cognitive impairment (PreCI) in elderly patients undergoing hip replacement.
- To assess the association between PreCI and postoperative cognitive dysfunction (POCD).
- To identify the incidence of cognitive decline 12 months post-surgery.
Main Methods:
- Prospective observational study of 300 elderly hip replacement patients and 51 controls.
- Neuropsychological testing pre-surgery and at 7 days, 3 months, and 12 months post-surgery.
- PreCI defined as ≥2 SD decline on ≥2 tests; POCD and cognitive decline assessed using reliable change index.
Main Results:
- Prevalence of PreCI was 32% (95% CI, 23 to 43%).
- POCD occurred in 17% at 7 days and 10% at 3 months. Cognitive decline at 12 months was 3%.
- Patients with PreCI showed significantly higher rates of POCD and 12-month cognitive decline.
Conclusions:
- Preexisting cognitive impairment is a significant risk factor for POCD and cognitive decline in elderly surgical patients.
- PreCI serves as a reliable predictor of postoperative cognitive issues.
- The incidence of long-term cognitive decline at 12 months is relatively low in this cohort.
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