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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
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Uveitic crystalline maculopathy.

Chris Or1, Andrew W Kirker1, Farzin Forooghian2

  • 1Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Eye Care Centre, Vancouver General Hospital, University of British Columbia, 2550 Willow Street, Vancouver, BC V5Z 3N9 Canada.

Journal of Ophthalmic Inflammation and Infection
|April 11, 2015
PubMed
Summary
This summary is machine-generated.

A novel cause of crystalline maculopathy, termed uveitic crystalline maculopathy, is presented. This condition may arise from intermediate uveitis, leading to crystal deposition in the macula due to blood-retinal barrier breakdown.

Keywords:
Blood-retinal barrierCrystalline maculopathyUveitic crystalline maculopathyUveitis

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Uveitis

Background:

  • Crystalline maculopathy is a rare condition affecting vision.
  • The etiology of crystalline maculopathy is not fully understood.

Purpose of the Study:

  • To report a novel case of crystalline maculopathy.
  • To propose a new classification for this condition.

Main Methods:

  • Case report of a 52-year-old Japanese female with decreased vision.
  • Ophthalmic examination including funduscopy, optical coherence tomography (OCT), and ultra-widefield fluorescein angiography (UWFA).

Main Results:

  • The patient presented with intraretinal crystals and vitritis in the left eye.
  • OCT revealed intraretinal fluid cysts and crystals.
  • UWFA showed features consistent with intermediate uveitis.

Conclusions:

  • A novel category of crystalline retinopathy, termed uveitic crystalline maculopathy, is proposed.
  • Uveitis may lead to blood-retinal barrier breakdown, causing crystal deposition in the macula.