Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

10.7K
10.7K
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.8K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.9K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.9K
Phases of Wound Repair01:28

Phases of Wound Repair

9.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD31<sup>+</sup> Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A 3D Human Bone and Bone Marrow-on-a-Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Callus formation during healing is guided by local strain: a retrospective clinical observation.

BMC musculoskeletal disorders·2026
Same author

Primary fixation stability evaluation of pre-bent titanium miniplate configurations in mandibular reconstruction.

Frontiers in bioengineering and biotechnology·2026
Same author

Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.

Bioactive materials·2026
Same author

Novel image registration approach for combining 2D Osterix and collagen bundles images with 3D micro-CT.

JBMR plus·2026

Related Experiment Video

Updated: Apr 15, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

814

The connection between cellular mechanoregulation and tissue patterns during bone healing.

Felix Repp1, Andreas Vetter2,3, Georg N Duda4

  • 1Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany. felix.repp@mpikg.mpg.de.

Medical & Biological Engineering & Computing
|April 12, 2015
PubMed
Summary

Computer simulations explored how mechanical stimuli influence bone healing. Varying mechanoregulation parameters showed minimal impact on overall tissue patterns, with cartilage differences noted in intermediate healing stages.

Keywords:
Bone healingCell sensitivityMechanical stimulusSimulationTissue differentiation

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

9.7K

Related Experiment Videos

Last Updated: Apr 15, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

814
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

9.7K

Area of Science:

  • Biomechanical engineering
  • Regenerative medicine
  • Computational biology

Background:

  • Secondary bone healing involves complex tissue formation influenced by mechanical stimuli.
  • Understanding cellular mechanoregulation is key to predicting healing outcomes.
  • Previous models often lack comprehensive simulation parameters for full healing progression.

Purpose of the Study:

  • To investigate the impact of different mechanoregulation hypotheses on tissue patterns during secondary bone healing using computer simulations.
  • To assess the influence of time delays, variable mechanosensitivity, and mechanical independence on healing progression.
  • To refine computational models for bone healing by incorporating ossification and resorption.

Main Methods:

  • Utilized a phenomenological model for ossification (endochondral and intramembranous) and bone resorption.
  • Simulated sheep tibial osteotomy healing based on experimental histological data.
  • Tested three mechanoregulation variations: time delay, variable cell sensitivity, and mechanical independence.

Main Results:

  • Simulations showed no qualitative differences in tissue pattern development across the tested mechanoregulation scenarios.
  • The amount and location of cartilage varied most significantly during intermediate healing phases.
  • Healing progression remained largely unchanged when tissue maturation was independent of mechanical stimulus.

Conclusions:

  • The computational model suggests that variations in cellular mechanoregulation have limited impact on the overall progression of secondary bone healing.
  • Cartilage formation is the most sensitive indicator of mechanoregulation differences during intermediate healing.
  • Mechanical independence in tissue maturation does not significantly alter the course of bone healing.