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Related Experiment Video

Updated: Apr 15, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Optic nerve aspergillosis.

Lisi Yuan¹, Richard A Prayson¹

¹Cleveland Clinic Department of Anatomic Pathology, L25 9500 Euclid Avenue, Cleveland, OH 44122, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|April 12, 2015

Summary

This summary is machine-generated.

Optic nerve Aspergillosis, a rare fungal infection, was diagnosed post-mortem in a woman with immunosuppression. Aspergillus species invaded the optic nerve, causing vision loss despite steroid treatment.

Keywords:

Abscess Aspergillosis Aspergillus Optic nerve

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Area of Science:

Ophthalmology
Mycology
Neurology

Background:

Aspergillus is a common airborne fungus that typically causes disease in immunocompromised individuals.
Optic nerve Aspergillosis is a rare but serious infection affecting vision.

Observation:

A 55-year-old woman with hypertension and migraines presented with unilateral headache, blurred vision, and scotoma.
Initial investigations including temporal artery biopsy and MRI for optic nerve thickening were inconclusive.
Steroid treatment improved headache but not vision.

Findings:

Autopsy revealed an abscess involving the left optic nerve and extending to the optic chiasm.
Histopathology confirmed angioinvasive fungal hyphae consistent with Aspergillus species.
No evidence of systemic vasculitis or infection was found.

Implications:

This case highlights the importance of considering fungal infections like Aspergillosis in the differential diagnosis of optic nerve disorders, especially in at-risk patients.
Early diagnosis and appropriate antifungal therapy are crucial for managing optic nerve Aspergillosis to prevent vision loss.