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Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
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Addictive disorders after Roux-en-Y gastric bypass
James E Mitchell1, Kristine Steffen1, Scott Engel1
1Neuropsychiatric Research Institute and the University of North Dakota School of Medicine, Fargo, North Dakota.
Summary
Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is linked to new alcohol use disorders (AUD) and behavioral addictions in 8-18% of patients. Further research is needed for non-drug related disorders.
Area of Science:
- Bariatric Surgery Outcomes
- Addictive Disorders Research
- Gastroenterology
Background:
- Growing evidence suggests post-bariatric surgery addictive disorders, including traditional and behavioral addictions.
- Prevalence data for behavioral addictions post-RYGB remain largely unpublished.
Purpose of the Study:
- To determine the prevalence of addictive behaviors in adults following Roux-en-Y gastric bypass (RYGB) surgery.
Main Methods:
- 201 adult RYGB patients provided data via Structured Clinical Interview for DSM-IV Axis I (SCID), Impulsive Control Disorder Modules, and self-report measures (AUDIT).
- Assessment covered pre-surgery status and the first three years post-surgery.
Main Results:
- 16.0% (8.0%) developed alcohol use disorder (AUD) within 3 years post-RYGB, with 43.8% having no prior AUD history.
- Using both SCID and AUDIT identified AUD in 18.4% (32 patients), 40.6% of whom had no prior history.
- 9.5% (19 patients) developed other behavioral addictive disorders post-surgery, 31.6% with no prior history.
Conclusions:
- Data indicate a significant risk for developing AUD after bariatric surgery.
- More extensive research is required to understand the risks of non-drug-related addictive disorders post-RYGB.
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