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MicroRNAs as the fine-tuners of Src oncogenic signalling

Chitose Oneyama1, Masato Okada2

  • 1Division of Microbiology and Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan and Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan Division of Microbiology and Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan and Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan coneyama@aichi-cc.jp.

Journal of Biochemistry
|April 12, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate the signaling molecule Src, which is linked to cancer progression. Understanding these miRNA-Src interactions may reveal new therapeutic targets for human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular Src (c-Src) tyrosine kinase is upregulated in various human cancers, but its precise role in tumor progression is unclear.
  • MicroRNAs (miRNAs) are emerging as tumor suppressors that regulate signaling molecules, and their aberrant expression is common in cancer.

Purpose of the Study:

  • To review the role of miRNAs in Src signaling pathways across different cancers.
  • To elucidate the molecular mechanisms underlying miRNA-Src interactions and their therapeutic implications.

Main Methods:

  • Literature review of recent studies on miRNAs involved in Src signaling.
  • Analysis of miRNA target genes and their interplay with Src signaling pathways.

Main Results:

  • Several miRNAs have been identified as regulators of Src signaling in cancer.
  • These miRNAs target genes involved in crucial cancer-related pathways.
  • The interplay between miRNAs and Src signaling offers potential therapeutic strategies.

Conclusions:

  • miRNAs play a significant role in regulating Src signaling in human cancers.
  • Targeting miRNA-Src interactions presents a promising avenue for novel cancer therapeutics.
Keywords:
Srccancer signallingmTORmicroRNAproto-oncogene

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