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Updated: Apr 15, 2026

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
Published on: April 7, 2023
[Detection of chromosomal aneuploidies in spontaneous abortion samples by fluorescence in situ hybridization]
Ping Wei1, Yunxing Li, Chun Chen
1Sichuan Provincial Maternal and Child Health Hospital, Chengdu, Sichuan 610041, P.R. China. lyunxing2002@sina.cn.
Objective:
To analyze 81 spontaneous abortion samples with fluorescence in situ hybridization (FISH).
Methods:
Chromosome 13, 21, 16, 22, 18, X and Y probes were used to detect the samples.
Results:
FISH was successful in 80 cases (98.77%). Among these, 35 (43.75%) had an abnormal karyotype, which included 19 autosomal aneuploidies, 6 sex chromosome aneuploidies, 9 triploidies and 1 tetraploidy.
Conclusion:
FISH is a rapid and easy method for detecting chromosomal aneuploidies in spontaneous abortion samples, and has a higher detection rate in early spontaneous abortion samples.

