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Updated: Apr 15, 2026
Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
Published on: January 12, 2024
Emerging targets in osteoarthritis therapy
Mary B Goldring1, Francis Berenbaum2
1Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, NY, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA.
Abstract:
Osteoarthritis (OA) is a destructive joint disease in which the initiation may be attributed to direct injury and mechanical disruption of joint tissues, but the progressive changes are dependent on active cell-mediated processes that can be observed or inferred during the generally long time-course of the disease. Based on clinical observations and experimental studies, it is now recognized a that it is possible for individual patients to exhibit common sets of symptoms and structural abnormalities due to distinct pathophysiological pathways that act independently or in combination. Recent research that has focused on the underlying mechanisms involving biochemical cross talk among the cartilage, synovium, bone, and other joint tissues within a background of poorly characterized genetic factors will be addressed in this review.
Insights
Osteoarthritis (OA) involves joint tissue damage, with disease progression driven by cell-mediated processes. Different patients may show similar OA symptoms due to unique underlying pathological pathways.
Area of Science:
- Biomedical Science
- Orthopedics
- Rheumatology
Background:
- Osteoarthritis (OA) is a destructive joint disease.
- Disease initiation can stem from direct injury or mechanical disruption.
- Progressive changes in OA are driven by active cell-mediated processes.
Purpose of the Study:
- To review recent research on OA mechanisms.
- To explore biochemical crosstalk among joint tissues.
- To address the role of genetic factors in OA.
Main Methods:
- Review of clinical observations and experimental studies.
- Analysis of pathophysiological pathways in OA.
- Investigation of cell-mediated processes in joint tissues.
Main Results:
- OA progression is dependent on active cell-mediated processes.
- Distinct pathophysiological pathways can lead to common OA symptoms and structural abnormalities.
- Biochemical crosstalk among cartilage, synovium, and bone plays a role in OA.
Conclusions:
- Understanding diverse OA pathophysiological pathways is crucial.
- Cell-mediated processes are key drivers of OA progression.
- Further research into genetic factors and tissue crosstalk is warranted.
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