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Updated: Apr 15, 2026

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
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Emerging targets in osteoarthritis therapy.

Mary B Goldring1, Francis Berenbaum2

  • 1Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, NY, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA.

Current Opinion in Pharmacology
|April 13, 2015
PubMed
Summary

Osteoarthritis (OA) involves joint tissue damage, with disease progression driven by cell-mediated processes. Different patients may show similar OA symptoms due to unique underlying pathological pathways.

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Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
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Area of Science:

  • Biomedical Science
  • Orthopedics
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a destructive joint disease.
  • Disease initiation can stem from direct injury or mechanical disruption.
  • Progressive changes in OA are driven by active cell-mediated processes.

Purpose of the Study:

  • To review recent research on OA mechanisms.
  • To explore biochemical crosstalk among joint tissues.
  • To address the role of genetic factors in OA.

Main Methods:

  • Review of clinical observations and experimental studies.
  • Analysis of pathophysiological pathways in OA.
  • Investigation of cell-mediated processes in joint tissues.

Main Results:

  • OA progression is dependent on active cell-mediated processes.
  • Distinct pathophysiological pathways can lead to common OA symptoms and structural abnormalities.
  • Biochemical crosstalk among cartilage, synovium, and bone plays a role in OA.

Conclusions:

  • Understanding diverse OA pathophysiological pathways is crucial.
  • Cell-mediated processes are key drivers of OA progression.
  • Further research into genetic factors and tissue crosstalk is warranted.