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Updated: Apr 15, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
16.8K
Survival outcomes in patients with multiple primary melanomas
C J Rowe1,2, M H Law3, J M Palmer2
1UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Woolloongabba, Qld, Australia.
Summary
Patients with multiple primary melanomas (MPM) face a higher risk of melanoma-related death compared to those with a single primary melanoma (SPM). This finding holds true even when accounting for other known risk factors.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Multiple primary melanomas (MPM) are diagnosed in a significant number of patients.
- The prognostic impact of MPM on patient survival remains largely undetermined.
Purpose of the Study:
- To investigate if patients with MPM have a poorer survival rate compared to those with a single invasive primary melanoma (SPM).
Main Methods:
- A retrospective cohort study utilizing Australian registry data.
- Melanoma-specific survival analysis was conducted on 1068 stage I and II melanoma patients.
- Four statistical models were employed, adjusting for established prognostic factors.
Main Results:
- MPM was identified in 17.8% of patients, predominantly in males and older individuals.
- After adjusting for age, sex, and Breslow thickness, MPM emerged as a significant predictor of melanoma mortality (HR=2.76, P=0.017).
Conclusions:
- Multiple primary melanomas are associated with an increased risk of death from melanoma.
- This increased risk is independent of other known prognostic indicators for melanoma survival.
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