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Related Experiment Video

Updated: Apr 15, 2026

A Mouse Distraction Osteogenesis Model
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Mandibular distraction osteogenesis assisted by cell-based tissue engineering: a systematic review.

B C Tee1, Z Sun

  • 1Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH, USA.

Orthodontics & Craniofacial Research
|April 14, 2015
PubMed
Summary

Mesenchymal stem cell (MSC) transplantation shows promise in enhancing mandibular distraction osteogenesis (MDO) bone regeneration in animal studies. Further research is needed to optimize MDO protocols and cell transplantation methods.

Keywords:
mandibular distraction osteogenesisstem cellsystematic reviewtissue engineering

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Area of Science:

  • Regenerative Medicine
  • Oral and Maxillofacial Surgery
  • Biomedical Engineering

Background:

  • Mandibular distraction osteogenesis (MDO) is a surgical technique used to correct mandibular deformities.
  • Mesenchymal stem cells (MSCs) have shown potential in promoting bone regeneration.
  • Combining MDO with MSC transplantation is an emerging area of research.

Purpose of the Study:

  • To review recent advancements in MDO assisted by MSC transplantation.
  • To identify the limitations and challenges in current research.
  • To provide insights for future investigations in this field.

Main Methods:

  • Systematic literature search of PubMed, Scopus, and Cochrane databases up to August 2014.
  • Inclusion of studies investigating MDO and cell transplantation in animal models.
  • Qualitative synthesis of 19 selected studies.

Main Results:

  • The majority of studies reported enhanced bone regeneration with MSC transplantation during MDO.
  • Significant variations were observed in MDO protocols, cell delivery methods, and outcome assessments across studies.
  • All included studies exhibited certain biases, highlighting the need for standardized methodologies.

Conclusions:

  • Animal studies suggest that MSC transplantation can augment MDO bone regeneration.
  • Further investigation is required to address inconsistencies in animal models, MDO protocols, and cell transplantation parameters.
  • Standardization of research methodologies is crucial for advancing this therapeutic approach.