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Pyonephrosis due to Chryseobacterium gleum: a first case report.
S Garg, S B Appannanavar, B Mohan
1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian Journal of Medical Microbiology
|April 14, 2015
Summary
This study reports the first case of AmpC-producing Chryseobacterium gleum causing pyonephrosis. The bacterium showed unique antimicrobial resistance, highlighting the need for susceptibility testing in Nonfermentative Gram-Negative Bacilli infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Chryseobacterium species are ubiquitous environmental bacteria.
- Clinical data on Chryseobacterium isolation from human samples is limited.
- Nonfermentative Gram-Negative Bacilli (NFGNBs) can cause opportunistic infections.
Observation:
- A case of pyonephrosis in a patient with bilateral nephrolithiasis and a double J (DJ) stent is presented.
- The causative agent was identified as an AmpC-producing Chryseobacterium gleum isolate.
- The isolate exhibited resistance to vancomycin, erythromycin, clindamycin, carbapenems, and ciprofloxacin.
Findings:
- The Chryseobacterium gleum isolate was susceptible to tetracycline and minocycline.
- The patient recovered successfully after treatment with tetracycline, without requiring DJ stent removal.
- Environmental surveillance did not identify a nosocomial source for the infection.
Implications:
- This case demonstrates a novel clinical presentation of Chryseobacterium gleum infection.
- The unique antimicrobial susceptibility pattern underscores the importance of in vitro testing for NFGNBs.
- Tailored antimicrobial therapy based on susceptibility testing is crucial for effective treatment of these pathogens.
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