Human brown adipose tissue assessed by simple, noninvasive near-infrared time-resolved spectroscopy
Shinsuke Nirengi1, Takeshi Yoneshiro, Hiroki Sugie
1Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Objective:
Human brown adipose tissue (BAT) activity has been typically evaluated by (18) F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed tomography (CT). However, FDG-PET/CT has serious limitations (e.g., radiation and cold exposure). This study evaluated BAT density using near-infrared time-resolved spectroscopy (NIRTRS ), a simple and noninvasive method of measuring the indices of tissue hemoglobin concentration [total-Hb] and mitochondrial density (µs ').
Methods:
The NIRTRS parameters at 760, 800, and 830 nm in the supraclavicular region potentially containing BAT were evaluated. First, the NIRTRS parameters were compared at 27 °C and during a 2-h cold exposure (19 °C) in 18 men. Then, NIRTRS parameters at 27 °C were compared with mean standardized uptake values (SUVmean ) assessed by FDG-PET/CT after the 2-h cold exposure (19 °C) in 29 men.
Results:
There was no significant difference between the NIRTRS parameters at 27 °C and 19°C. The [total-Hb] and µs ' were significantly correlated to SUVmean (r = 0.73 and r = 0.64, respectively). A receiver operating characteristic analysis revealed that the sensitivity (75.0-82.4%), specificity (91.7-100%), and accuracy (82.8-86.2%) of the NIRTRS parameters were all good to determine the NIRTRS reliability.
Conclusions:
Our novel NIRTRS method is noninvasive and simple and can reliably assess human BAT density in the supraclavicular region.
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