Matrix normalized MALDI-TOF quantification of a fluorotelomer-based acrylate polymer

Area of Science:

• Environmental Chemistry
• Polymer Science
• Analytical Chemistry

Background:

• Fluorotelomer-based acrylate polymers (FTACPs) are suspected sources of perfluoroalkyl carboxylates (PFCAs).
• Previous studies relied on indirect measurements, leading to uncertainty in FTACP environmental fate assessment.

Purpose of the Study:

• To develop the first direct quantitative analysis method for FTACPs.
• To establish a reliable method for assessing the environmental impact of FTACPs.

Main Methods:

• Development of a quantitative matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry method.
• Normalization of polymer signals to a matrix-sodium cluster (P(N)) without an internal standard polymer.
• Creation of calibration curves using dithranol solution for sample preparation.

Main Results:

• Achieved quantification of poly(8:2 FTAC-co-HDA) within 25% of theoretical concentration.
• Demonstrated high linearity for calibration curves (R(2) > 0.98).
• Minimized sample-to-sample variability inherent in MALDI-TOF analysis.

Conclusions:

• The developed MALDI-TOF method provides the first direct quantification of FTACPs.
• This method offers a more accurate approach to evaluating the environmental fate and degradation of FTACPs.
• Enables precise monitoring of potential environmental contaminants derived from FTACPs.