Bidens pilosa Formulation Improves Blood Homeostasis and β -Cell Function in Men: A Pilot Study

Area of Science:

• Phytochemistry
• Metabolic disorders
• Clinical nutrition

Background:

• Bidens pilosa (B. pilosa) is traditionally used for diabetes management.
• Previous research focused on phytochemistry and animal models, lacking human clinical trials.

Purpose of the Study:

• To evaluate the efficacy and safety of a B. pilosa formulation in diabetic subjects.
• To assess its impact on glycemic control markers and beta-cell function.

Main Methods:

• Human clinical trial involving diabetic and healthy subjects.
• Measurement of fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c (HbA1c).
• Assessment of beta-cell function using the homeostatic model assessment (HOMA).

Main Results:

• The B. pilosa formulation significantly reduced FBG and HbA1c in diabetic individuals.
• It increased fasting serum insulin in healthy subjects but showed no adverse effects.
• Combination therapy with B. pilosa and antidiabetic drugs improved glycemic control.
• HOMA data indicated improved beta-cell function.

Conclusions:

• B. pilosa formulation demonstrates potential as an antidiabetes treatment.
• Its mechanism may involve enhancing beta-cell function.
• The formulation appears safe for use in healthy individuals.