Related Experiment Video
Updated: Apr 15, 2026
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
Published on: January 3, 2025
Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models
Linsheng Yu1, Yanyan Fan, Guanghua Ye
1Xi'an Jiaotong University Health Science Center (LY, ZW), School of Forensic Science and Medicine, Xi'an, China; Department of Forensic Medicine (LY, YF, GY, JL, XF, KL, MD), Wenzhou Medical University, Wenzhou, China; and Institute of Forensic Science (LY, YF, GY, JL, XF, KL, MD), Wenzhou Medical University, Wenzhou, China.
Abstract:
Curcumin, extracted from South Asian spice turmeric, has been determined to have the promising ability in antioxidation and anti-inflammation. However, the effect of curcumin on treating brain damage has been not reported. In this article, the aim was to evaluate the effect of curcumin on cell apoptosis in rats exposed to hypoxia-hypercapnia and explore the therapeutic potential of curcumin in hypoxia-hypercapnia brain damage (HHBD). Sprague Dawley rats were randomly assigned into 3 groups: control group, hypoxia-hypercapnia group and curcumin group. The Fas/FasL expressions in HHBD rats treated by curcumin were measured by immunohistochemical staining and western blotting. The pathological changes of brain cells were observed by transmission electron microscope. Rats with HHBD showed significant increase of Fas/FasL expression and ultrastructural changes in brain tissue cells. Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and HHBD-induced brain edema. Curcumin may be a potential therapeutic alternative for HHBD.
