Association between the FGB gene polymorphism and ischemic stroke: a meta-analysis

Area of Science:

• Genetics
• Neurology
• Cardiovascular Research

Background:

• Ischemic stroke is a leading cause of disability and death worldwide.
• Genetic factors play a crucial role in stroke etiology.
• The beta-fibrinogen (FGB) gene is implicated in hemostasis and thrombosis, relevant to stroke pathogenesis.

Purpose of the Study:

• To investigate the association between the beta-fibrinogen (FGB) gene polymorphism -148C>T and the risk of ischemic stroke.
• To synthesize existing evidence through a comprehensive meta-analysis.

Main Methods:

• Systematic literature search of PubMed, EMBASE, and CKNI databases.
• Inclusion of 12 independent case-control studies with 1536 ischemic stroke patients and 1329 controls.
• Meta-analysis to assess the odds ratio and confidence intervals for the FGB -148C>T polymorphism and ischemic stroke risk.

Main Results:

• The FGB -148C>T polymorphism was significantly associated with an increased risk of ischemic stroke.
• Specific genotype comparisons revealed significant risk associations (e.g., TT vs. CC+CT: OR=3.01, P=0.01).
• Allele analysis indicated that the T allele confers a higher risk (T vs. C: OR=1.32, P<0.0001).

Conclusions:

• The -148C>T polymorphism in the FGB gene is a validated genetic susceptibility marker for ischemic stroke.
• This finding contributes to understanding the genetic underpinnings of ischemic stroke.
• Further research may explore targeted interventions based on genetic predisposition.